Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice.

نویسندگان

  • F N Lauw
  • S Florquin
  • P Speelman
  • S J van Deventer
  • T van der Poll
چکیده

In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

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عنوان ژورنال:
  • Infection and immunity

دوره 69 9  شماره 

صفحات  -

تاریخ انتشار 2001